PD-L1 positivity in tumor cells

Clinical features

Patients’ age group, in years

Summary table
	Younger age	Older age
Mean	1.3	4.0
Standard deviation	8.1	18.9
Median	0.0	0.0
Interquartile range	0.0	0.0
Minimum	0.0	0.0
Maximum	52.5	100.0

Mann-Whitney U test for the sum of ranks
	Value
U-statistic	526
P statistic	1.8e-01

Patients’ sex

Summary table
	Female	Male
Mean	5.3	1.3
Standard deviation	22.9	7.5
Median	0.0	0.0
Interquartile range	0.0	0.0
Minimum	0.0	0.0
Maximum	100.0	52.5

Mann-Whitney U test for the sum of ranks
	Value
U-statistic	515
P statistic	4.7e-01

Patients’ race

Summary table
	Caucasian	African-American	Asian	Other
Mean	3.1	0	0	0
Standard deviation	15.3	0	NA	0
Median	0.0	0	0	0
Interquartile range	0.0	0	0	0
Minimum	0.0	0	0	0
Maximum	100.0	0	0	0

Kruskal-Wallis rank sum test
	Value
Statistic	2.626
Parameter	3
P statistic	0.45

History of other malignancies

Summary table
	No other tumor	Prostate cancer	Other tumor
Mean	2.7	0.1	1.3
Standard deviation	14.8	0.2	3.5
Median	0.0	0.0	0.0
Interquartile range	0.0	0.0	0.1
Minimum	0.0	0.0	0.0
Maximum	100.0	0.5	10.0

Kruskal-Wallis rank sum test
	Value
Statistic	1.942
Parameter	2
P statistic	0.38

Pathologic features

Tumor size group

Summary table
	Smaller size	Larger size
Mean	0.0	5.0
Standard deviation	0.2	19.4
Median	0.0	0.0
Interquartile range	0.0	0.0
Minimum	0.0	0.0
Maximum	1.0	100.0

Mann-Whitney U test for the sum of ranks
	Value
U-statistic	517
P statistic	9.8e-02

Multifocality

Summary table
	Single tumor	Multifocal tumor
Mean	2.8	0
Standard deviation	14.5	0
Median	0.0	0
Interquartile range	0.0	0
Minimum	0.0	0
Maximum	100.0	0

Mann-Whitney U test for the sum of ranks
	Value
U-statistic	306
P statistic	2.6e-01

Fuhrman grade

Summary table
	G1	G2	G3	G4
Mean	0	0.1	7.1	0
Standard deviation	0	0.2	23.1	0
Median	0	0.0	0.0	0
Interquartile range	0	0.0	0.0	0
Minimum	0	0.0	0.0	0
Maximum	0	1.0	100.0	0

Kruskal-Wallis rank sum test
	Value
Statistic	1.658
Parameter	3
P statistic	0.65

pT stage

Summary table
	pT1	pT2	pT3
Mean	1.1	0	6.5
Standard deviation	7.4	0	24.2
Median	0.0	0	0.0
Interquartile range	0.0	0	0.0
Minimum	0.0	0	0.0
Maximum	52.5	0	100.0

Kruskal-Wallis rank sum test
	Value
Statistic	1.085
Parameter	2
P statistic	0.58

Surgical margin

Summary table
	Negative margin	Positive margin
Mean	2.6	0
Standard deviation	13.9	0
Median	0.0	0
Interquartile range	0.0	0
Minimum	0.0	0
Maximum	100.0	0

Mann-Whitney U test for the sum of ranks
	Value
U-statistic	146
P statistic	4.7e-01

Outcome features

Tumor progression

Summary table
	No tumor progression	Tumor progression
Mean	2.7	0
Standard deviation	14.4	0
Median	0.0	0
Interquartile range	0.0	0
Minimum	0.0	0
Maximum	100.0	0

Mann-Whitney U test for the sum of ranks
	Value
U-statistic	276
P statistic	2.9e-01

Overall mortality

Summary table
	ANOD + AWD	DOC + DOD
Mean	2.9	0
Standard deviation	14.7	0
Median	0.0	0
Interquartile range	0.0	0
Minimum	0.0	0
Maximum	100.0	0

Mann-Whitney U test for the sum of ranks
	Value
U-statistic	396
P statistic	1.8e-01

Cancer-related mortality

Summary table
	ANOD + AWD + DOC	DOD
Mean	2.4	0
Standard deviation	13.6	0
Median	0.0	0
Interquartile range	0.0	0
Minimum	0.0	0
Maximum	100.0	0

Mann-Whitney U test for the sum of ranks
	Value
U-statistic	76
P statistic	6.3e-01

PD-L1 H-score in tumor cells

Clinical features

Patients’ age group, in years

Summary table
	Younger age	Older age
Mean	1.3	4.0
Standard deviation	8.1	18.9
Median	0.0	0.0
Interquartile range	0.0	0.0
Minimum	0.0	0.0
Maximum	52.5	100.0

Mann-Whitney U test for the sum of ranks
	Value
U-statistic	526
P statistic	1.8e-01

Patients’ sex

Summary table
	Female	Male
Mean	5.3	1.3
Standard deviation	22.9	7.5
Median	0.0	0.0
Interquartile range	0.0	0.0
Minimum	0.0	0.0
Maximum	100.0	52.5

Mann-Whitney U test for the sum of ranks
	Value
U-statistic	515
P statistic	4.7e-01

Patients’ race

Summary table
	Caucasian	African-American	Asian	Other
Mean	3.1	0	0	0
Standard deviation	15.3	0	NA	0
Median	0.0	0	0	0
Interquartile range	0.0	0	0	0
Minimum	0.0	0	0	0
Maximum	100.0	0	0	0

Kruskal-Wallis rank sum test
	Value
Statistic	2.626
Parameter	3
P statistic	0.45

History of other malignancies

Summary table
	No other tumor	Prostate cancer	Other tumor
Mean	2.7	0.1	1.3
Standard deviation	14.8	0.2	3.5
Median	0.0	0.0	0.0
Interquartile range	0.0	0.0	0.1
Minimum	0.0	0.0	0.0
Maximum	100.0	0.5	10.0

Kruskal-Wallis rank sum test
	Value
Statistic	1.942
Parameter	2
P statistic	0.38

Pathologic features

Tumor size group

Summary table
	Smaller size	Larger size
Mean	0.0	5.0
Standard deviation	0.2	19.4
Median	0.0	0.0
Interquartile range	0.0	0.0
Minimum	0.0	0.0
Maximum	1.0	100.0

Mann-Whitney U test for the sum of ranks
	Value
U-statistic	517
P statistic	9.8e-02

Multifocality

Summary table
	Single tumor	Multifocal tumor
Mean	2.8	0
Standard deviation	14.5	0
Median	0.0	0
Interquartile range	0.0	0
Minimum	0.0	0
Maximum	100.0	0

Mann-Whitney U test for the sum of ranks
	Value
U-statistic	306
P statistic	2.6e-01

Fuhrman grade

Summary table
	G1	G2	G3	G4
Mean	0	0.1	7.1	0
Standard deviation	0	0.2	23.1	0
Median	0	0.0	0.0	0
Interquartile range	0	0.0	0.0	0
Minimum	0	0.0	0.0	0
Maximum	0	1.0	100.0	0

Kruskal-Wallis rank sum test
	Value
Statistic	1.658
Parameter	3
P statistic	0.65

pT stage

Summary table
	pT1	pT2	pT3
Mean	1.1	0	6.5
Standard deviation	7.4	0	24.2
Median	0.0	0	0.0
Interquartile range	0.0	0	0.0
Minimum	0.0	0	0.0
Maximum	52.5	0	100.0

Kruskal-Wallis rank sum test
	Value
Statistic	1.085
Parameter	2
P statistic	0.58

Surgical margin

Summary table
	Negative margin	Positive margin
Mean	2.6	0
Standard deviation	13.9	0
Median	0.0	0
Interquartile range	0.0	0
Minimum	0.0	0
Maximum	100.0	0

Mann-Whitney U test for the sum of ranks
	Value
U-statistic	146
P statistic	4.7e-01

Outcome features

Tumor progression

Summary table
	No tumor progression	Tumor progression
Mean	2.7	0
Standard deviation	14.4	0
Median	0.0	0
Interquartile range	0.0	0
Minimum	0.0	0
Maximum	100.0	0

Mann-Whitney U test for the sum of ranks
	Value
U-statistic	276
P statistic	2.9e-01

Overall mortality

Summary table
	ANOD + AWD	DOC + DOD
Mean	2.9	0
Standard deviation	14.7	0
Median	0.0	0
Interquartile range	0.0	0
Minimum	0.0	0
Maximum	100.0	0

Mann-Whitney U test for the sum of ranks
	Value
U-statistic	396
P statistic	1.8e-01

Cancer-related mortality

Summary table
	ANOD + AWD + DOC	DOD
Mean	2.4	0
Standard deviation	13.6	0
Median	0.0	0
Interquartile range	0.0	0
Minimum	0.0	0
Maximum	100.0	0

Mann-Whitney U test for the sum of ranks
	Value
U-statistic	76
P statistic	6.3e-01

PD-L1 positivity in stromal cells

Clinical features

Patients’ age group, in years

Summary table
	Younger age	Older age
Mean	2.8	0.7
Standard deviation	11.0	2.4
Median	0.0	0.0
Interquartile range	0.0	0.0
Minimum	0.0	0.0
Maximum	60.0	10.0

Mann-Whitney U test for the sum of ranks
	Value
U-statistic	306
P statistic	7.3e-01

Patients’ sex

Summary table
	Female	Male
Mean	5.8	0.9
Standard deviation	18.0	3.0
Median	0.0	0.0
Interquartile range	0.5	0.0
Minimum	0.0	0.0
Maximum	60.0	15.0

Mann-Whitney U test for the sum of ranks
	Value
U-statistic	239
P statistic	4e-01

Patients’ race

Summary table
	Caucasian	African-American	Asian	Other
Mean	2.2	0	0	7.5
Standard deviation	9.8	0	NA	10.6
Median	0.0	0	0	7.5
Interquartile range	0.0	0	0	7.5
Minimum	0.0	0	0	0.0
Maximum	60.0	0	0	15.0

Kruskal-Wallis rank sum test
	Value
Statistic	4.204
Parameter	3
P statistic	0.24

History of other malignancies

Summary table
	No other tumor	Prostate cancer	Other tumor
Mean	2.4	0	0.6
Standard deviation	9.7	0	1.3
Median	0.0	0	0.0
Interquartile range	0.0	0	0.0
Minimum	0.0	0	0.0
Maximum	60.0	0	3.0

Kruskal-Wallis rank sum test
	Value
Statistic	0.9242
Parameter	2
P statistic	0.63

Pathologic features

Tumor size group

Summary table
	Smaller size	Larger size
Mean	3.3	0.9
Standard deviation	12.5	2.3
Median	0.0	0.0
Interquartile range	0.0	0.0
Minimum	0.0	0.0
Maximum	60.0	10.0

Mann-Whitney U test for the sum of ranks
	Value
U-statistic	292
P statistic	8.2e-01

Multifocality

Summary table
	Single tumor	Multifocal tumor
Mean	2.3	0
Standard deviation	9.3	0
Median	0.0	0
Interquartile range	0.0	0
Minimum	0.0	0
Maximum	60.0	0

Mann-Whitney U test for the sum of ranks
	Value
U-statistic	132
P statistic	2.8e-01

Fuhrman grade

Summary table
	G1	G2	G3	G4
Mean	15	2.7	0.6	0
Standard deviation	NA	11.6	1.4	0
Median	15	0.0	0.0	0
Interquartile range	0	0.0	0.0	0
Minimum	15	0.0	0.0	0
Maximum	15	60.0	5.0	0

Kruskal-Wallis rank sum test
	Value
Statistic	6.359
Parameter	3
P statistic	0.095

pT stage

Summary table
	pT1	pT2	pT3
Mean	2.9	0	0.3
Standard deviation	10.7	0	0.8
Median	0.0	0	0.0
Interquartile range	0.0	0	0.0
Minimum	0.0	0	0.0
Maximum	60.0	0	3.0

Kruskal-Wallis rank sum test
	Value
Statistic	0.8985
Parameter	2
P statistic	0.64

Surgical margin

Summary table
	Negative margin	Positive margin
Mean	2.1	0
Standard deviation	9.0	0
Median	0.0	0
Interquartile range	0.0	0
Minimum	0.0	0
Maximum	60.0	0

Mann-Whitney U test for the sum of ranks
	Value
U-statistic	56
P statistic	5.2e-01

Outcome features

Tumor progression

Summary table
	No tumor progression	Tumor progression
Mean	2.3	0
Standard deviation	9.3	0
Median	0.0	0
Interquartile range	0.0	0
Minimum	0.0	0
Maximum	60.0	0

Mann-Whitney U test for the sum of ranks
	Value
U-statistic	159
P statistic	2.4e-01

Overall mortality

Summary table
	ANOD + AWD	DOC + DOD
Mean	2.4	0.1
Standard deviation	9.5	0.4
Median	0.0	0.0
Interquartile range	0.0	0.0
Minimum	0.0	0.0
Maximum	60.0	1.0

Mann-Whitney U test for the sum of ranks
	Value
U-statistic	182
P statistic	5.8e-01

Cancer-related mortality

Summary table
	ANOD + AWD + DOC	DOD
Mean	2.1	0
Standard deviation	9.0	0
Median	0.0	0
Interquartile range	0.0	0
Minimum	0.0	0
Maximum	60.0	0

Mann-Whitney U test for the sum of ranks
	Value
U-statistic	57
P statistic	5.3e-01