FOXP3 positivity in intratumoral lymphocytes

Clinical features

Patients’ age group, in years

Summary table
Younger age Older age
Mean 2.1 2.7
Standard deviation 2.5 3.2
Median 1.5 1.5
Interquartile range 3.4 3.5
Minimum 0.0 0.0
Maximum 12.0 12.5
Mann-Whitney U test for the sum of ranks
Value
U-statistic 547
P statistic 6.2e-01

Patients’ sex

Summary table
Female Male
Mean 1.8 2.5
Standard deviation 2.2 2.9
Median 1.0 1.5
Interquartile range 2.5 3.0
Minimum 0.0 0.0
Maximum 7.0 12.5
Mann-Whitney U test for the sum of ranks
Value
U-statistic 416
P statistic 3.7e-01

Patients’ race

Summary table
Caucasian African-American Asian Other
Mean 2.4 2.5 3.5 0.3
Standard deviation 2.9 2.4 NA 0.6
Median 1.5 1.8 3.5 0.0
Interquartile range 3.4 3.5 0.0 0.5
Minimum 0.0 0.0 3.5 0.0
Maximum 12.5 6.5 3.5 1.0
Kruskal-Wallis rank sum test
Value
Statistic 3.812
Parameter 3
P statistic 0.28

History of other malignancies

Summary table
No other tumor Prostate cancer Other tumor
Mean 2.1 5.2 2.3
Standard deviation 2.3 4.8 3.6
Median 1.5 5.0 0.5
Interquartile range 3.5 5.5 3.1
Minimum 0.0 1.0 0.0
Maximum 12.0 12.5 10.0
Kruskal-Wallis rank sum test
Value
Statistic 3.292
Parameter 2
P statistic 0.19

Pathologic features

Tumor size group

Summary table
Smaller size Larger size
Mean 2.1 2.6
Standard deviation 2.8 2.8
Median 1.0 2.0
Interquartile range 3.1 3.0
Minimum 0.0 0.0
Maximum 12.5 12.0
Mann-Whitney U test for the sum of ranks
Value
U-statistic 482
P statistic 1.8e-01

Multifocality

Summary table
Single tumor Multifocal tumor
Mean 2.2 3.8
Standard deviation 2.8 2.6
Median 1.5 4.0
Interquartile range 3.1 4.5
Minimum 0.0 0.0
Maximum 12.5 7.0
Mann-Whitney U test for the sum of ranks
Value
U-statistic 155
P statistic 3.9e-02

Fuhrman grade

Summary table
G1 G2 G3 G4
Mean 0 2.0 3.1 4.0
Standard deviation 0 2.5 3.1 2.8
Median 0 1.0 2.0 4.0
Interquartile range 0 3.4 3.0 2.0
Minimum 0 0.0 0.0 2.0
Maximum 0 12.5 12.0 6.0
Kruskal-Wallis rank sum test
Value
Statistic 7.476
Parameter 3
P statistic 0.058

pT stage

Summary table
pT1 pT2 pT3
Mean 2.1 5.2 2.5
Standard deviation 2.8 1.1 2.6
Median 1.2 5.2 2.0
Interquartile range 3.0 0.8 3.0
Minimum 0.0 4.5 0.0
Maximum 12.5 6.0 10.0
Kruskal-Wallis rank sum test
Value
Statistic 4.189
Parameter 2
P statistic 0.12

Surgical margin

Summary table
Negative margin Positive margin
Mean 2.1 5.5
Standard deviation 2.5 4.9
Median 1.5 4.2
Interquartile range 3.0 3.2
Minimum 0.0 1.0
Maximum 12.0 12.5
Mann-Whitney U test for the sum of ranks
Value
U-statistic 58.5
P statistic 6.5e-02

Outcome features

Tumor progression

Summary table
No tumor progression Tumor progression
Mean 2.4 2.4
Standard deviation 2.8 2.4
Median 1.5 1.8
Interquartile range 3.5 3.5
Minimum 0.0 0.0
Maximum 12.5 6.5
Mann-Whitney U test for the sum of ranks
Value
U-statistic 234
P statistic 8.6e-01

Overall mortality

Summary table
ANOD + AWD DOC + DOD
Mean 2.3 2.6
Standard deviation 2.9 2.3
Median 1.5 2.0
Interquartile range 3.4 3.6
Minimum 0.0 0.0
Maximum 12.5 6.5
Mann-Whitney U test for the sum of ranks
Value
U-statistic 298
P statistic 4.3e-01

FOXP3 positivity in stromal lymphocytes

Clinical features

Patients’ age group, in years

Summary table
Younger age Older age
Mean 1.7 0.4
Standard deviation 3.3 1.1
Median 0.0 0.0
Interquartile range 1.0 0.0
Minimum 0.0 0.0
Maximum 15.0 3.5
Mann-Whitney U test for the sum of ranks
Value
U-statistic 166
P statistic 1.6e-01

Patients’ sex

Summary table
Female Male
Mean 1.0 1.5
Standard deviation 1.8 3.3
Median 0.0 0.0
Interquartile range 0.8 1.0
Minimum 0.0 0.0
Maximum 5.0 15.0
Mann-Whitney U test for the sum of ranks
Value
U-statistic 117
P statistic 6.1e-01

Patients’ race

Summary table
Caucasian African-American Asian Other
Mean 1.7 0 1 0.3
Standard deviation 3.3 0 NA 0.6
Median 0.0 0 1 0.0
Interquartile range 1.8 0 0 0.5
Minimum 0.0 0 1 0.0
Maximum 15.0 0 1 1.0
Kruskal-Wallis rank sum test
Value
Statistic 4.219
Parameter 3
P statistic 0.24

History of other malignancies

Summary table
No other tumor Prostate cancer Other tumor
Mean 1.5 0 0.9
Standard deviation 3.2 0 1.8
Median 0.0 0 0.0
Interquartile range 1.0 0 0.9
Minimum 0.0 0 0.0
Maximum 15.0 0 3.5
Kruskal-Wallis rank sum test
Value
Statistic 1.533
Parameter 2
P statistic 0.46

Pathologic features

Tumor size group

Summary table
Smaller size Larger size
Mean 0.6 2.6
Standard deviation 1.3 4.4
Median 0.0 0.0
Interquartile range 1.0 3.5
Minimum 0.0 0.0
Maximum 5.0 15.0
Mann-Whitney U test for the sum of ranks
Value
U-statistic 110
P statistic 2.1e-01

Multifocality

Summary table
Single tumor Multifocal tumor
Mean 1.3 2.5
Standard deviation 3.0 3.5
Median 0.0 2.5
Interquartile range 1.0 2.5
Minimum 0.0 0.0
Maximum 15.0 5.0
Mann-Whitney U test for the sum of ranks
Value
U-statistic 25
P statistic 5.5e-01

Fuhrman grade

Summary table
G1 G2 G3 G4
Mean 0.5 0.8 2.8 NaN
Standard deviation 0.7 1.5 4.7 NA
Median 0.5 0.0 1.0 NA
Interquartile range 0.5 1.0 3.0 NA
Minimum 0.0 0.0 0.0 Inf
Maximum 1.0 5.0 15.0 -Inf
Kruskal-Wallis rank sum test
Value
Statistic 2.108
Parameter 2
P statistic 0.35

pT stage

Summary table
pT1 pT2 pT3
Mean 1.3 8 0.6
Standard deviation 3.1 NA 1.3
Median 0.0 8 0.0
Interquartile range 1.0 0 0.5
Minimum 0.0 8 0.0
Maximum 15.0 8 3.5
Kruskal-Wallis rank sum test
Value
Statistic 3.555
Parameter 2
P statistic 0.17

Surgical margin

Summary table
Negative margin Positive margin
Mean 1.4 0
Standard deviation 3.0 NA
Median 0.0 0
Interquartile range 1.0 0
Minimum 0.0 0
Maximum 15.0 0
Mann-Whitney U test for the sum of ranks
Value
U-statistic 23.5
P statistic 4.9e-01

Outcome features

Tumor progression

Summary table
No tumor progression Tumor progression
Mean 1.4 0.8
Standard deviation 3.1 0.5
Median 0.0 1.0
Interquartile range 1.0 0.2
Minimum 0.0 0.0
Maximum 15.0 1.0
Mann-Whitney U test for the sum of ranks
Value
U-statistic 48.5
P statistic 3.9e-01

Overall mortality

Summary table
ANOD + AWD DOC + DOD
Mean 1.5 0.2
Standard deviation 3.1 0.5
Median 0.0 0.0
Interquartile range 1.0 0.2
Minimum 0.0 0.0
Maximum 15.0 1.0
Mann-Whitney U test for the sum of ranks
Value
U-statistic 77.5
P statistic 4.5e-01