Tumor progression

Unadjusted model

HR Lower .95 Upper .95 P value
Age, per 1 year increase 1.1 1 1.1 0.0011
Sex: Female vs Male 1.1 0.63 2 0.7
Location: Ureter vs Pelvis 1.2 0.66 2.1 0.58
Location: Pelvis-ureter vs Pelvis 11 2.4 52 0.0023
pT stage: High stage vs Low stage 3.7 2 7 0.000051
Lymphovascular invasion: Present vs Absent 2.7 1.5 4.8 0.00064
Lymph nodes metastasis: Present vs Absent 2 0.94 4.4 0.071
IGF1R: Positive vs Negative 1.4 0.74 2.6 0.31

Note: WHO grade was not included in the regression model for tumor progression due to the absence of low-grade cases that progressed.

Adjusted model

HR Lower .95 Upper .95 P value
Age, per 1 year increase 1.1 1 1.1 0.005
Sex: Female vs Male 0.99 0.5 2 0.97
Location: Ureter vs Pelvis 0.86 0.46 1.6 0.65
Location: Pelvis-ureter vs Pelvis 6.7 1.4 33 0.019
pT stage: High stage vs Low stage 2.7 1.3 5.7 0.011
Lymphovascular invasion: Present vs Absent 2.3 0.98 5.4 0.057
Lymph nodes metastasis: Present vs Absent 0.84 0.33 2.1 0.71
IGF1R: Positive vs Negative 1.5 0.75 2.9 0.27

Note: WHO grade was not included in the regression model for tumor progression due to the absence of low-grade cases that progressed.

Cancer-specific mortality

Unadjusted model

HR Lower .95 Upper .95 P value
Age, per 1 year increase 1 0.99 1.1 0.11
Sex: Female vs Male 0.75 0.35 1.6 0.46
Location: Ureter vs Pelvis 1.2 0.58 2.5 0.61
Location: Pelvis-ureter vs Pelvis 2.3 0.3 18 0.42
pT stage: High stage vs Low stage 18 4.2 74 0.000092
WHO Grade: High grade vs low grade 7.8 1.1 57 0.044
Lymphovascular invasion: Present vs Absent 5.6 2.5 13 0.00003
Lymph nodes metastasis: Present vs Absent 2.8 1.2 6.5 0.019
IGF1R: Positive vs Negative 1.3 0.57 2.8 0.57

Adjusted model

HR Lower .95 Upper .95 P value
Age, per 1 year increase 1 0.96 1.1 0.56
Sex: Female vs Male 0.76 0.31 1.9 0.55
Location: Ureter vs Pelvis 0.92 0.42 2 0.83
Location: Pelvis-ureter vs Pelvis 1.2 0.13 10 0.89
pT stage: High stage vs Low stage 14 2.9 68 0.00095
WHO Grade: High grade vs low grade 8.3 1.1 63 0.041
Lymphovascular invasion: Present vs Absent 1.8 0.63 5.2 0.27
Lymph nodes metastasis: Present vs Absent 1.2 0.43 3.1 0.77
IGF1R: Positive vs Negative 2.1 0.86 5 0.1