Clinical features

Age

Summary table
IGF1R Negative IGF1R Positive
Mean 67.1 71.2
Standard deviation 9.4 8.5
Median 67.0 72.0
Interquartile range 15.2 12.0
Minimum 51.0 48.0
Maximum 84.0 87.0
Mann-Whitney U test for the sum of ranks
Value
U-statistic 769
P statistic 4.3e-02

Sex

Summary table
IGF1R Negative (%) IGF1R Positive (%)
Male 19 (63.3) 41 (59.4)
Female 11 (36.7) 28 (40.6)
Pearson’s Chi-squared test with Yates’ continuity correction
Value
Statistic 0.02028
Parameter 1
P statistic 0.89

Pathologic features

Tumor location

Summary table
IGF1R Negative (%) IGF1R Positive (%)
Pelvis 16 (53.3) 29 (42)
Ureter 14 (46.7) 36 (52.2)
Pelvis-ureter 0 (0) 4 (5.8)
Pearson’s Chi-squared test
Value
Statistic 2.453
Parameter 2
P statistic 0.29

pT stage

Summary table
IGF1R Negative (%) IGF1R Positive (%)
pTa 4 (13.3) 15 (21.7)
pT1 6 (20) 12 (17.4)
pT2 2 (6.7) 6 (8.7)
pT3 17 (56.7) 31 (44.9)
pT4 1 (3.3) 5 (7.2)
Pearson’s Chi-squared test
Value
Statistic 2.077
Parameter 4
P statistic 0.72

High pT stage

Summary table
IGF1R Negative (%) IGF1R Positive (%)
Low pT (pT0-pT2) 12 (40) 33 (47.8)
High pT (pT3-pT4) 18 (60) 36 (52.2)
Pearson’s Chi-squared test with Yates’ continuity correction
Value
Statistic 0.2491
Parameter 1
P statistic 0.62

Histologic grade

Summary table
IGF1R Negative (%) IGF1R Positive (%)
Grade 1 1 (3.3) 6 (8.7)
Grade 2 12 (40) 27 (39.1)
Grade 3 17 (56.7) 36 (52.2)
Pearson’s Chi-squared test
Value
Statistic 0.9332
Parameter 2
P statistic 0.63

High histologic grade

Summary table
IGF1R Negative (%) IGF1R Positive (%)
Low grade 4 (13.3) 11 (15.9)
High grade 26 (86.7) 58 (84.1)
Pearson’s Chi-squared test with Yates’ continuity correction
Value
Statistic 0.0007686
Parameter 1
P statistic 0.98

Lymph nodes metastasis

Summary table
IGF1R Negative (%) IGF1R Positive (%)
No Lymph node metastasis 27 (90) 57 (86.4)
Lymph node mestastasis 3 (10) 9 (13.6)
Pearson’s Chi-squared test with Yates’ continuity correction
Value
Statistic 0.02771
Parameter 1
P statistic 0.87

Lymphovascular invasion

Summary table
IGF1R Negative (%) IGF1R Positive (%)
No lymphovascular invasion 20 (66.7) 39 (56.5)
Lymphovascular invasion 10 (33.3) 30 (43.5)
Pearson’s Chi-squared test with Yates’ continuity correction
Value
Statistic 0.522
Parameter 1
P statistic 0.47

Outcome features

Tumor recurrence

Summary table
IGF1R Negative (%) IGF1R Positive (%)
No tumor recurrence 17 (56.7) 48 (71.6)
Tumor recurrence 13 (43.3) 19 (28.4)
Pearson’s Chi-squared test with Yates’ continuity correction
Value
Statistic 1.479
Parameter 1
P statistic 0.22

Tumor progression

Summary table
IGF1R Negative (%) IGF1R Positive (%)
No tumor progression 10 (38.5) 24 (42.1)
Tumor progression 16 (61.5) 33 (57.9)
Pearson’s Chi-squared test with Yates’ continuity correction
Value
Statistic 0.005253
Parameter 1
P statistic 0.94

Patients’ outcome

Summary table
IGF1R Negative (%) IGF1R Positive (%)
AWD 0 (0) 5 (7.2)
DOC 1 (3.3) 2 (2.9)
DOD 9 (30) 21 (30.4)
LFU 12 (40) 11 (15.9)
NED 8 (26.7) 30 (43.5)
Pearson’s Chi-squared test
Value
Statistic 8.937
Parameter 4
P statistic 0.063

Cancer-specific mortality

Summary table
IGF1R Negative (%) IGF1R Positive (%)
NED + AWD + DOC + LFU 21 (70) 48 (69.6)
DOD 9 (30) 21 (30.4)
Pearson’s Chi-squared test with Yates’ continuity correction
Value
Statistic 6.096e-31
Parameter 1
P statistic 1

Overall mortality

Summary table
IGF1R Negative (%) IGF1R Positive (%)
NED + AWD + LFU 20 (66.7) 46 (66.7)
DOC + DOD 10 (33.3) 23 (33.3)
Pearson’s Chi-squared test
Value
Statistic 0
Parameter 1
P statistic 1